Immune reconstitution after anti-thymocyte globulin-conditioned hematopoietic cell transplantation
نویسندگان
چکیده
منابع مشابه
Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Of note, new developments such as umbilical cord blood or haploidentical grafts were associated with prolonged immunodeficiency due to delayed immune reconstitution, raising ...
متن کاملImmune reconstitution after autologous hematopoietic stem cell transplantation.
Autologous hematopoietic stem cell transplantation has proved to be an effective treatment for certain hematologic malignancies. However, relapse rates are high during the first year after transplantation. These relapses are attributed to the failure of high-dose chemotherapy to eradicate minimal residual malignant disease. In allogeneic hematopoietic stem cell transplantation, the higher antit...
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Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infectio...
متن کاملImmune reconstitution and immunotherapy after autologous hematopoietic stem cell transplantation.
APPROXIMATELY 10,000 autologous hematopoietic stem cell (HSC) transplants are performed worldwide each year for malignant diseases.1 Results of randomized trials in recent years suggest that high-dose chemotherapy followed by infusion of autologous HSCs can offer prolonged disease-free survival in hematologic malignancies including non-Hodgkin’s lymphoma in relapse,2 acute myelogenous leukemia,...
متن کاملAllogeneic hematopoietic cell transplantation after failed autologous transplant for lymphoma using total lymphoid irradiation and anti-thymocyte globulin conditioning
We describe 47 patients with lymphoma and failed prior autologous hematopoietic cell transplantation (HCT) who received TLI-ATG conditioning followed by allogeneic HCT. Thirtytwo patients had non-Hodgkin lymphoma (NHL; diffuse large B cell lymphoma [n=19], T-cell NHL [n=6], mantle cell lymphoma [n= 4], or other B-cell subtypes [n=3]), and 15 had Hodgkin lymphoma. The median follow-up was 4.9 (r...
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ژورنال
عنوان ژورنال: Cytotherapy
سال: 2012
ISSN: 1465-3249
DOI: 10.3109/14653249.2012.715243